Dectin-1/CLEC7A 蛋白, Mouse (HEK293, His)

Dectin-1/CLEC7A protein has (1->3)-β-D-glucan binding and pattern recognition receptor activity, participates in immune responses and recognizes specific structures. It regulates cytokine production and responds to fungal pathogens while being active on the cell surface. Dectin-1/CLEC7A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Dectin-1/CLEC7A protein, expressed by HEK293 , with N-His labeled tag. The total length of Dectin-1/CLEC7A Protein, Mouse (HEK293, His) is 176 a.a., with molecular weight of 30-37 kDa.

Dectin-1/CLEC7A 蛋白预计具有 (1->3)-β-D-葡聚糖结合活性和模式识别受体活性，使其能够识别特定结构并参与免疫反应。预计它还会在多种过程中发挥作用，例如吞噬和识别，以及积极调节参与炎症反应和真菌病原体反应的细胞因子的产生。从功能上讲，已知它在细胞表面具有活性。该蛋白在多种组织中表达，包括大脑、肠道、四肢、肌肉组织和腹侧灰角。在人类中，直系同源基因 CLEC7A 的突变与曲霉病和慢性皮肤粘膜念珠菌病有关，表明其在针对这些疾病的免疫防御中的重要性（基因组资源联盟，2022 年 4 月）。此外，Dectin-1/CLEC7A 蛋白在多种组织中广泛表达，包括肺 (RPKM 2.7)、膀胱 (RPKM 1.9) 和 16 个其他组织。

Mouse

HEK293

N-His

NP_064392.2 (F69-L244)

56644  [NCBI]

30-37 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.