DR3/TNFRSF25 蛋白, Human (177a.a, HEK293, Fc)

DR3/TNFRSF25 Protein, the receptor for TNFSF12/APO3L/TWEAK, interacts with adapter TRADD, activating NF-kappa-B and inducing apoptosis. It may crucially regulate lymphocyte homeostasis. Forming homodimers, it strongly interacts with TNFRSF1 and TRADD via death domains, initiating distinct apoptosis and NF-kappa-B signaling cascades. Interaction with BAG4 contributes to its multifaceted cellular response roles. DR3/TNFRSF25 Protein, Human (177a.a, HEK293, Fc) is the recombinant human-derived DR3/TNFRSF25 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DR3/TNFRSF25 Protein, Human (177a.a, HEK293, Fc) is 177 a.a., with molecular weight of 50-55 kDa.

DR3/TNFRSF25 蛋白作为 TNFSF12/APO3L/TWEAK 的受体，并直接与接头 TRADD 相互作用。这种相互作用导致 NF-kappa-B 的激活并诱导细胞凋亡。该蛋白质可能在调节淋巴细胞稳态中发挥至关重要的作用。它形成同二聚体，并通过死亡结构域与 TNFRSF1 和 TRADD 表现出强烈的相互作用，启动参与细胞凋亡和 NF-kappa-B 信号传导的不同信号级联。此外，DR3/TNFRSF25 与 BAG4 相互作用，有助于其在细胞反应中发挥多方面的作用。

Human

HEK293

C-hFc

Q93038 (Q25-F201)

8718  [NCBI]

QGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMF

50-55 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.