DSG-2/Desmoglein-2 蛋白, Human (HEK293, His)

DSG-2 is an important component of intercellular desmosome junctions and actively participates in complex interactions between plaque proteins and intermediate filaments, thereby promoting strong intercellular adhesion. By binding to these structural components, DSG-2 helps maintain cell cohesion and tissue integrity. DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is the recombinant human-derived DSG-2/Desmoglein-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSG-2/Desmoglein-2 Protein, Human (HEK293, His) is 560 a.a., with molecular weight of 70-80 kDa.

Desmoglein-2 (DSG-2) 是细胞间桥粒连接的重要组成部分，在介导细胞间粘附方面发挥着关键作用。在这些连接处，DSG-2 参与促进斑块蛋白和中间丝之间的相互作用，有助于组织的结构完整性和稳定性。值得注意的是，DSG-2 与 Plakophilin-2 (PKP2) 形成相互作用，突显其参与负责桥粒组装和维护的复杂分子网络。这种相互作用强调了 DSG-2 在确保适当的细胞粘附和组织凝聚方面的重要性，强调其在调节各种组织细胞间连接中的关键作用。（参考：提供的资料）

Immobilized Human DSG-2 at 0.5 μg/mL (100μL/Well) on the plate. Dose response curve for Anti-DSG-2 Antibody with the EC₅₀ <19.5 ng/ml determined by ELISA.

Human

HEK293

C-His

Q14126 (A50-G609)

1829  [NCBI]

70-80 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.