1. 重组蛋白
  2. Cytokines and Growth Factors
  3. TNF Superfamily
  4. TNF Receptor Superfamily
  5. EDAR
  6. EDAR 蛋白, Cynomolgus (HEK293, Fc)

EDAR 蛋白, Cynomolgus (HEK293, Fc)

目录号: HY-P76895
产品使用指南

EDAR 蛋白是 EDA 同工型 A1 的受体,结合后激活 NF-kappa-B 和 JNK 信号通路,引发多种细胞反应。它还可能导致不依赖半胱天冬酶的细胞死亡。EDAR 与 EDARADD 形成复合物,并与 TRAF1、TRAF2、TRAF3 和 NIK 等信号分子结合,强调其参与复杂的信号级联反应。EDAR 蛋白, Cynomolgus (HEK293, Fc) 是重组的 EDAR 蛋白,由 HEK293 表达,带有 C-hFc 标签。EDAR 蛋白, Cynomolgus (HEK293, Fc) 全长 187 个氨基酸,分子量为 60-64 kDa。

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描述

EDAR Protein, a receptor for EDA isoform A1, activates NF-kappa-B and JNK signaling pathways upon binding, eliciting diverse cellular responses. It may also contribute to caspase-independent cell death. EDAR forms a complex with EDARADD and associates with signaling molecules like TRAF1, TRAF2, TRAF3, and NIK, highlighting its participation in intricate signaling cascades. EDAR Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDAR Protein, Cynomolgus (HEK293, Fc) is 187 a.a., with molecular weight of 60-64 kDa.

研究背景

EDAR 是专门针对 EDA 同工型 A1 的受体,使其与 EDA 同工型 A2 区别开来。结合后,EDAR 促进 NF-kappa-B 和 JNK 信号通路的激活,可能导致各种细胞反应。此外,EDAR 可能在促进不依赖 caspase 的细胞死亡中发挥作用。该受体与 EDARADD 形成复合物,并与 TRAF1、TRAF2、TRAF3 和 NIK 等关键信号分子相关,表明其参与复杂的信号级联反应。

种属

Cynomolgus

表达系统

HEK293

标签

C-hFc

蛋白编号

A0A2K5VY41 (M1-A187)

基因 ID

102120238  [NCBI]

蛋白结构
N-term
EDAR (M1-A187)
Accession # A0A2K5VY41
hFc
C-term
同用名
Tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; EDAR
分子量

60-64 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

EDAR Protein, Cynomolgus (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
EDAR Protein, Cynomolgus (HEK293, Fc)
目录号:
HY-P76895
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