EDNRA 蛋白, Human (P.pastoris, His)

EDNRA Protein, a receptor for endothelin-1, activates a phosphatidylinositol-calcium second messenger system through association with G proteins. Its binding affinities follow the order: ET1 > ET2 >> ET3. Additionally, EDNRA interacts with HDAC7 and KAT5. EDNRA Protein, Human (P.pastoris, His) is the recombinant human-derived EDNRA protein, expressed by P. pastoris , with N-His labeled tag. The total length of EDNRA Protein, Human (P.pastoris, His) is 60 a.a., with molecular weight of ~62 kDa.

EDNRA 是细胞信号传导的关键参与者，作为内皮素-1 的受体发挥作用，通过 G 蛋白执行其作用并启动磷脂酰肌醇-钙第二信使系统。该受体表现出不同的结合亲和力，其中 ET1 具有最高的亲和力，其次是 ET2 和 ET3。除了在内皮素信号转导中的典型功能外，EDNRA 还参与分子相互作用，与 HDAC7 和 KAT5 形成复合物，可能有助于复杂的细胞调节网络。内皮素-1 信号传导和蛋白质相互作用的融合凸显了 EDNRA 在协调不同细胞过程中的多方面作用。

Human

P. pastoris

N-His

P25101 (D21-K80)

1909  [NCBI]

DNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFK

Approximately 62 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in Tris-based buffer, 50% glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.