EGF 蛋白, Human (Solution, HEK293, N-hFc)

The Progranulin/PGRN protein is involved in a variety of cellular processes, including cell growth, inflammation, and neurodegeneration. It acts as a regulator of tissue repair and has been implicated in the pathogenesis of several diseases, including Alzheimer's disease and frontotemporal dementia. Progranulin/PGRN interacts with various receptors and signaling pathways to exert its effects on cellular function and disease progression. EGF Protein, Human (Solution, HEK293, N-hFc) is the recombinant human-derived EGF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of EGF Protein, Human (Solution, HEK293, N-hFc) is 53 a.a., with molecular weight of ~37 kDa.

EGF 蛋白是表皮生长因子超家族的成员，编码前蛋白原，经过蛋白水解加工产生 53 个氨基酸的表皮生长因子肽。作为一种有效的有丝分裂因子，该蛋白通过与细胞表面受体、表皮生长因子受体高亲和力结合，在各种细胞类型的生长、增殖和分化中发挥着至关重要的作用。该基因的缺陷与 4 型低镁血症有关，而失调则与某些癌症的生长和进展有关。选择性剪接产生多种转录物变体，包括至少一种编码经过蛋白水解加工的前蛋白原。值得注意的是，该基因表现出偏向表达，在肾脏 (RPKM 47.7)、胰腺 (RPKM 9.8) 和一种其他组织中表达水平升高，突出了其在这些生理环境中的潜在意义。

Measured in a cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblast cells and the ED₅₀ is typically 0.3-1.5 ng/mL.

Human

HEK293

N-hFc

NP_001954.2 (N971-R1023)

1950  [NCBI]

NSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELR

Approximately 37 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.