1. 重组蛋白
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. EGF
  5. EGF 蛋白, Human (HEK293, His)

EGF 蛋白, Human (HEK293, His)

目录号: HY-P704573
产品使用指南 技术支持

EGF 蛋白在体内和体外环境中均可作为多种表皮和上皮组织生长的有效刺激剂,同时促进细胞培养中特定成纤维细胞的增殖。这种多面蛋白还充当镁刺激激素,通过 EGFR 的参与和镁通道 TRPM6 的激活驱动肾远曲小管中的镁重吸收。EGF 蛋白, Human (HEK293, His) 是重组的 EGF 蛋白,由 HEK293 表达,带有 N-His 标签。

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描述

EGF proteins act as potent stimulators of growth in a variety of epidermal and epithelial tissues in both in vivo and in vitro settings, while promoting the proliferation of specific fibroblasts in cell culture. This multifaceted protein also acts as a magnesium stimulating hormone, driving magnesium reabsorption in the renal distal tubule through engagement of EGFR and activation of the magnesium channel TRPM6. EGF Protein, Human (HEK293, His) is the recombinant human-derived EGF protein, expressed by HEK293, with N-His labeled tag.

研究背景

GMP EGF 蛋白在体内和体外环境中成为多种表皮和上皮组织生长的有效刺激剂,同时促进细胞培养中特定成纤维细胞的增殖。这种多面蛋白还充当促镁激素,通过 EGFR 的参与和镁通道 TRPM6 的激活驱动肾远曲小管中的镁重吸收。值得注意的是,GMP EGF 蛋白具有在体外诱导池塘蜗牛 Lymnaea stagnalis 运动神经元神经突生长的能力。其分子相互作用包括与 EGFR 结合,从而促进 EGFR 二聚化,以及与 RHBDF2 相互作用,表明参与多种细胞过程。此外,GMP EGF 蛋白与 RHBDF1 结合,可能影响 EGF 在内质网中的保留,并通过内质网相关降解 (ERAD) 调节其降解。

种属

Human

表达系统

HEK293

标签

N-His

蛋白编号

P01133-1 (N971-R1023)

基因 ID

1950

蛋白结构
N-term
His
EGF (N971-R1023)
Accession # P01133
C-term
同用名
rHuEGF; Pro-epidermal growth factor; Urogastrone
预测分子量
8.3 kDa.
分子量

10-11 kDa

糖基化修饰
Yes
纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

EGF Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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EGF Protein, Human (HEK293, His)
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HY-P704573
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