Epiregulin 蛋白, Human (HEK293, Fc)

Epiregulin Protein, a ligand for EGFR and ERBB4, crucially influences inflammation, wound healing, tissue repair, and oocyte maturation. It stimulates tyrosine phosphorylation of both receptors, regulating angiogenesis, vascular remodeling, and cell proliferation. Interactions with EGFR and ERBB4 contribute to intricate signaling pathways, essential for diverse physiological responses and cellular functions. Epiregulin Protein, Human (HEK293, Fc) is the recombinant human-derived Epiregulin protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Epiregulin Protein, Human (HEK293, Fc) is 46 a.a., with molecular weight of ~35 kDa.

上皮调节蛋白是 EGF 受体 (EGFR) 和 ERBB4 的配体，在炎症、伤口愈合、组织修复和卵母细胞成熟等细胞过程中发挥着至关重要的作用。它通过刺激 EGFR 和 ERBB4 的酪氨酸磷酸化来实现这一目标。此外，上皮调节蛋白还参与血管生成、血管重塑和细胞增殖的调节。通过与 EGFR 和 ERBB4 的相互作用，上皮调节蛋白有助于形成对于各种生理反应和细胞功能至关重要的复杂信号传导途径。

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is <8 μg/mL.

• 
  Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is 0.7141 ng/mL, corresponding to a specific activity is 1.4×10⁶ units/mg.

Human

HEK293

N-hFc

O14944 (V63-L108)

2069  [NCBI]

VSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFL

Approximately 35 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.