1. 重组蛋白
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. Epiregulin
  5. Epiregulin 蛋白, Mouse (HEK293, hFc)

Epiregulin 蛋白, Mouse (HEK293, hFc)

目录号: HY-P75226
COA 产品使用指南

上皮调节蛋白是 EGFR 和 ERBB4 的配体,可诱导其酪氨酸磷酸化,在炎症、伤口愈合、组织修复和卵母细胞成熟中发挥关键作用。它调节血管生成、血管重塑和细胞增殖,强调其参与复杂的细胞信号传导途径。Epiregulin 蛋白, Mouse (HEK293, hFc) 是重组的 上皮调节蛋白,由 HEK293 表达,带有 N-hFc 标签。Epiregulin 蛋白, Mouse (HEK293, hFc) 全长 46 个氨基酸,分子量约为 ~37 kDa。

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描述

Epiregulin Protein, a ligand for EGFR and ERBB4, induces their tyrosine phosphorylation, playing a pivotal role in inflammation, wound healing, tissue repair, and oocyte maturation. It regulates angiogenesis, vascular remodeling, and cell proliferation, emphasizing its involvement in intricate cellular signaling pathways. Epiregulin Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Epiregulin protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Epiregulin Protein, Mouse (HEK293, hFc) is 46 a.a., with molecular weight of ~37 kDa.

研究背景

上皮调节蛋白作为 EGF 受体 (EGFR) 和 ERBB4 的配体,引发这些受体的酪氨酸磷酸化。这种多功能蛋白质在各种生理过程中发挥着关键作用,包括炎症、伤口愈合、组织修复和卵母细胞成熟,通过调节血管生成、血管重塑和细胞增殖发挥影响。它与 EGFR 和 ERBB4 的相互作用凸显了它参与复杂的细胞信号传导途径。

生物活性

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells and the ED50 is typically 0.5-2.5 μg/mL.

种属

Mouse

表达系统

HEK293

标签

N-hFc

蛋白编号

Q61521 (V56-L101)

基因 ID

13874  [NCBI]

蛋白结构
N-term
hFc
Epiregulin (V56-L101)
Accession # Q61521
C-term
同用名
Proepiregulin; Epiregulin; EPR; EREG
分子量

Approximately 37 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

溶液.

组分

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

N/A.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料

Epiregulin Protein, Mouse (HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Epiregulin Protein, Mouse (HEK293, hFc)
目录号:
HY-P75226
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