Ezrin/EZR 蛋白, Human

Ezrin (EZR) plays a crucial role in connecting major cytoskeletal structures to the plasma membrane and is particularly critical for the development of microvilli and membrane ruffles in epithelial cells. Ezrin cooperates with PLEKHG6 and is essential for normal macropinocytosis. Ezrin/EZR Protein, Human is the recombinant human-derived Ezrin/EZR protein, expressed by E. coli , with tag free.

Ezrin (EZR) 可能在建立主要细胞骨架结构和质膜之间的连接方面发挥着至关重要的作用。特别是在上皮细胞中，它对于顶极微绒毛和膜皱褶的发育至关重要。此外，与 PLEKHG6 合作，Ezrin 对于巨胞饮作用的正常过程是必需的。该蛋白质表现出头尾关联，将其 N 端和 C 端一半结合在一起，形成代表非活性形式的闭合构象。在这种状态下，Ezrin 无法与肌动蛋白或膜结合，这表明其功能激活存在调节机制。

Human

E. coli

Tag Free

P15311 (M1-L586)

7430  [NCBI]

Full Length

MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL

Approximately 82.0 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 10 mM Hepes, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.