FABP5/E-FABP 蛋白, Mouse (His)

FABP5, also known as E-FABP, acts as an intracellular carrier of long-chain fatty acids and related lipids and regulates ligand metabolism. In addition to cytoplasmic transport, it selectively transports fatty acids to the nucleus, activates nuclear receptors, and delivers retinoic acid to promote proliferation. FABP5/E-FABP Protein, Mouse (His) is the recombinant mouse-derived FABP5/E-FABP protein, expressed by E. coli , with N-6*His labeled tag. The total length of FABP5/E-FABP Protein, Mouse (His) is 135 a.a., with molecular weight of ~16 kDa.

FABP5，也称为 E-FABP，作为长链脂肪酸和相关活性脂质（包括内源性大麻素）的细胞内载体，从而调节它们结合的配体的代谢和作用。除了在细胞质运输中的作用之外，FABP5 还选择性地将特定脂肪酸从细胞质输送到细胞核，从而激活核受体。值得注意的是，它将视黄酸递送至核受体过氧化物酶体增殖物激活受体δ，促进增殖和存活。FABP5 的参与延伸到充当中央突触内源性大麻素的突触载体，从而控制逆行内源性大麻素信号传导。此外，FABP5 通过在炎症过程中通过 NF-κ-B 激活和前列腺素 E2 (PGE2) 生物合成调节 PTGES 诱导来调节炎症。还表明其在角质形成细胞分化中的潜在作用。

Data is not available.

Mouse

E. coli

N-6*His

Q05816 (M1-Q135)

16592  [NCBI]

MASLKDLEGKWRLMESHGFEEYMKELGVGLALRKMAAMAKPDCIITCDGNNITVKTESTVKTTVFSCNLGEKFDETTADGRKTETVCTFQDGALVQHQQWDGKESTITRKLKDGKMIVECVMNNATCTRVYEKVQ

Approximately 16 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.