FBP1 蛋白, Human (HEK293, His)

The FBP1 protein plays a crucial role in cellular processes by catalyzing the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate, acting as a rate-limiting enzyme in gluconeogenesis. In addition to playing a key role in glucose metabolism, FBP1 also plays an important role in regulating glucose sensing and insulin secretion in pancreatic β cells. FBP1 Protein, Human (HEK293, His) is the recombinant human-derived FBP1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FBP1 Protein, Human (HEK293, His) is 337 a.a., with molecular weight of 35-38 kDa.

FBP1蛋白是催化果糖1,6-二磷酸水解为果糖6-磷酸的关键酶，在糖异生过程中作为限速酶发挥着至关重要的作用。二价阳离子促进其酶活性。FBP1 是调节胰腺 β 细胞葡萄糖稳态和胰岛素分泌的重要组成部分，影响葡萄糖感应。此外，FBP1 还参与肝脏中甘油糖异生的调节。值得注意的是，这种蛋白质是食欲和肥胖的重要调节剂，因为营养过剩后肝脏中表达增加，导致循环饱腹感激素水平升高，刺激食欲的神经肽减少。这表明 FBP1 作为一种反馈机制来限制体重增加，以响应营养丰富。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

P09467 (A2-Q338)

2203  [NCBI]

ADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ

35-38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 1 mM DTT, 1 mM EDTA, 10% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.