Fc epsilon RIA/FCER1A 蛋白, Mouse (204a.a, HEK293, Fc)

Fc epsilon RIA/FCER1A protein is a high-affinity receptor for immunoglobulin epsilon/IgE and is critical for mediating IgE effector function. It activates and differentiates myeloid cells after binding IgE and cross-linking with antigens/allergens, causing mast cells, basophils, and eosinophils to secrete mediators and cytokines. Fc epsilon RIA/FCER1A Protein, Mouse (204a.a, HEK293, Fc) is the recombinant mouse-derived Fc epsilon RIA/FCER1A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Fc epsilon RIA/FCER1A Protein, Mouse (204a.a, HEK293, Fc) is 181 a.a., with molecular weight of ~64.07 kDa.

Fc epsilon RIA/FCER1A 蛋白是免疫球蛋白 epsilon/IgE 的高亲和力受体。它在介导骨髓细胞中 IgE 效应器功能中发挥着至关重要的作用。在与 IgE 结合并与抗原/过敏原交联后，它启动激活和分化骨髓细胞的信号通路。这种激活导致肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞分泌血管活性胺、脂质介质和细胞因子，从而促进炎症反应、组织重塑和针对微生物的细胞毒性。该蛋白质负责触发对过敏原的立即超敏反应，充当宿主针对蠕虫寄生虫、病原菌和毒液毒性的防御机制。然而，当失调时，它可能会导致有害的、危及生命的过敏和过敏反应。在结构上，Fc epsilon RIA/FCER1A 蛋白由一个四聚体组成，该四聚体包含一条 α 链、一条 β 链和两条二硫键连接的 γ 链。它通过 CH3 区域与 IGHE 相互作用。

Data is not available.

Mouse

HEK293

C-hFc

P20489 (A24-Q204)

14125  [NCBI]

ATEKSVLTLDPPWIRIFTGEKVTLSCYGNNHLQMNSTTKWIHNGTVSEVNSSHLVIVSATVQDSGKYICQKQGLFKSKPVYLNVTQDWLLLQTSADMVLVHGSFDIRCHGWKNWNVRKVIYYRNDHAFNYSYESPVSIREATLNDSGTYHCKGYLRQVKYESDKFRIAVVKAYKCKYYWLQ

Approximately 64.07 kDa

• 
  Greater than 85% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.