1. 重组蛋白
  2. CD Antigens Fc Receptors
  3. Macrophage CD Proteins Monocyte CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
  4. Fc gamma RII/CD32 FCGR2A/CD32a
  5. FCGR2A/CD32a
  6. Fc gamma RIIA/CD32a 蛋白, Human (CHO, His)

Fc gamma RIIA/CD32a 蛋白, Human (CHO, His)

目录号: HY-P76230
产品使用指南

Fc gamma RIIA/CD32a 蛋白起着关键作用,作为低亲和力受体特异性结合免疫球蛋白 gamma 的 Fc 区。它与 IgG 相互作用,启动针对病原体的细胞反应,这对于免疫调节至关重要。值得注意的是,该蛋白质促进调理抗原吞噬作用,有助于免疫防御。它与 IGHG1、INPP5D/SHIP1、INPPL1/SHIP2、APCS、FGR 和 HCK 结合,参与复杂的信号传导通路,突出其在协调不同免疫反应中的多方面作用。Fc gamma RIIA/CD32a 蛋白, Human (CHO, His) 是重组的 Fc gamma RIIA/CD32a 蛋白,由 CHO 表达,带有 C-His 标签。Fc gamma RIIA/CD32a 蛋白, Human (CHO, His) 全长 185 个氨基酸,分子量为 29-32 KDa。

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描述

Fc gamma RIIA/CD32a Protein plays a pivotal role, specifically binding to the Fc region of immunoglobulins gamma as a low-affinity receptor. Interacting with IgG, it initiates cellular responses against pathogens, crucial for immune modulation. Notably, the protein promotes opsonized antigen phagocytosis, contributing to immune defense. Engaging with IGHG1, INPP5D/SHIP1, INPPL1/SHIP2, APCS, FGR, and HCK, it participates in intricate signaling pathways, highlighting its multifaceted role in orchestrating diverse immune responses. Fc gamma RIIA/CD32a Protein, Human (CHO, His) is the recombinant human-derived Fc gamma RIIA/CD32a protein, expressed by CHO, with C-His labeled tag. The total length of Fc gamma RIIA/CD32a Protein, Human (CHO, His) is 185 a.a., with molecular weight of 29-32 KDa.

研究背景

Fc γ RIIA/CD32a 蛋白通过特异性结合免疫球蛋白 γ 的 Fc 区而发挥关键作用,充当低亲和力受体。通过与 IgG 相互作用,Fc gamma RIIA/CD32a 启动针对病原体和可溶性抗原的细胞反应,说明其在免疫调节中的重要作用。值得注意的是,该蛋白质促进调理抗原的吞噬作用,进一步促进免疫防御机制。此外,Fc gamma RIIA/CD32a 与 IGHG1、INPP5D/SHIP1、INPPL1/SHIP2、APCS、FGR 和 HCK 相互作用,表明其参与复杂的信号传导途径及其细胞功能的调节。这些多方面的相互作用强调了 Fc gamma RIIA/CD32a 在协调不同免疫反应中的重要性。

种属

Human

表达系统

CHO

标签

C-His

蛋白编号

P12318 (Q34-I218)

基因 ID
蛋白结构
N-term
CD32a (Q34-I218)
Accession # P12318
His
C-term
同用名
FCGR2A; CD32; CD32A; CDw32; IGFR2; fcRII-a; fc-gamma-RIIa; FCG2; FcGR; FCGR2; FCGR2A1; MGC23887; MGC30032
分子量

29-32 kDa.

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Fc gamma RIIA/CD32a Protein, Human (CHO, His)
目录号:
HY-P76230
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