1. 重组蛋白
  2. Fc Receptors
  3. FcRn
  4. FCGRT-B2M Heterodimer 蛋白, Rat (HEK293, His, solution)

FCGRT-B2M Heterodimer 蛋白, Rat (HEK293, His, solution)

目录号: HY-P75760
COA 产品使用指南

FCGRT-B2M 异二聚体蛋白是一种细胞表面受体,可与 IgG 和白蛋白相互作用,有助于有效的体液免疫。FCGRT-B2M Heterodimer 蛋白, Rat (HEK293, His, solution) 是重组的蛋白二聚体复合物,包含 FCGRT-B2M 异二聚体蛋白,由 HEK293 表达,带有 C-His 标签。FCGRT-B2M Heterodimer 蛋白, Rat (HEK293, His, solution) ,分子量分别约为 ~35 & 12 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 μg ¥1150 In-stock
20 μg ¥1840 In-stock
50 μg ¥3500 In-stock
100 μg   询价  

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描述

The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution), has molecular weight of ~35 & 12 kDa, respectively.

研究背景

FCGRT-B2M 异二聚体蛋白作为重要的细胞表面受体,促进被动体液免疫从母亲转移到新生儿。它识别单体免疫球蛋白 γ 的 Fc 区,选择性地从牛奶中摄取 IgG,特别是在肠上皮的顶端表面。形成的 FcRn-IgG 复合物穿过肠上皮进行转胞吞作用,将 IgGFcRn 释放到血液或组织液中。该过程通过回收 IgG 并延长其在循环中的半衰期,对有效的体液免疫做出了重大贡献。从机制上讲,单体 IgG 与内皮细胞和造血细胞酸性内体中的 FcRn 结合,促进 IgG 循环到细胞表面,将其释放到循环中。值得注意的是,除了在 IgG 稳态中发挥作用外,FCGRT-B2M 异二聚体还通过与白蛋白相互作用调节另一种丰富的循环蛋白白蛋白/ALB 的稳态。FcRn 复合物由两个亚基 p51 和 p14(相当于 β-2-微球蛋白)组成,形成 MHC I 类异二聚体,突出了其在免疫和蛋白质稳态中的关键作用。

种属

Rat

表达系统

HEK293

标签

C-His

蛋白编号

P13599 (A23-S298)&P07151 (I21-M119)

基因 ID

29558  [NCBI]&24223  [NCBI]

同用名
FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin
分子量

Approximately 35&12 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

溶液

组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

N/A.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料

FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FCGRT-B2M Heterodimer Protein, Rat (HEK293, His, solution)
目录号:
HY-P75760
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