FCRN 蛋白, Mouse (HEK293, His)

The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCRN Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived FCRN protein, expressed by HEK293 , with C-6*His labeled tag. FCRN Protein, Mouse (HEK293, His), has molecular weight of 42-58 & 12 kDa, respectively.

FCRN 是一种重要的细胞表面受体，有助于被动体液免疫从母亲转移到新生儿。它识别单体免疫球蛋白 γ 的 Fc 区，选择性地从牛奶中摄取 IgG，特别是在肠上皮的顶端表面。所得的 FcRn-IgG 复合物穿过肠上皮进行转胞吞作用，将 IgG 从 FcRn 释放到血液或组织液中。该过程通过回收 IgG 并延长其在循环中的半衰期，对有效的体液免疫做出了重大贡献。从机制上讲，单体 IgG 与内皮细胞和造血细胞酸性内体中的 FcRn 结合，促进 IgG 循环到细胞表面，将其释放到循环中。值得注意的是，除了在 IgG 稳态中发挥作用外，FcRn 复合物由两个亚基 p51 和 p14（相当于 β-2-微球蛋白）组成，形成 MHC I 类异二聚体，突出了其在免疫和蛋白质稳态中的关键作用。此外，FCRN 与白蛋白/ALB 相互作用，调节另一种最丰富的循环蛋白的稳态。

Mouse

HEK293

C-6*His

Q61559 (Ser22-Val301)&P01887 (Ile21-Met119)

14132  [NCBI]&12010  [NCBI]

SETRPPLMYHLTAVSNPSTGLPSFWATGWLGPQQYLTYNSLRQEADPCGAWMWENQVSWYWEKETTDLKSKEQLFLEALKTLEKILNGTYTLQGLLGCELASDNSSVPTAVFALNGEEFMKFNPRIGNWTGEWPETEIVANLWMKQPDAARKESEFLLNSCPERLLGHLERGRRNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSSARSSVPVV
&:
IQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM

42-58&12 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.