FGF-19 蛋白, Human

FGF-19 Protein, Human could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.

成纤维细胞生长因子 19（FGF19，在啮齿动物中也称为 FGF15）是控制营养代谢的成纤维细胞生长因子亚家族的成员。FGF19 与由 FGF 受体 4 (FGFR4) 和称为 β-Klotho 的辅助受体组成的受体复合物结合，这两种受体均在肝脏中高度表达。FGF19 是一种肠因子，当胆汁酸被回肠吸收时合成并释放。FGF19 刺激肝蛋白和糖原合成，但不诱导脂肪生成。FGF19 激活生理上重要的、不依赖胰岛素的内分泌途径，调节肝蛋白和糖原代谢^[1]。

The ED₅₀ is <288.5 ng/mL as measured by murine Balb/c 3T3 cells, corresponding to a specific activity of >3.46 × 10³ units/mg.

Human

E. coli

Tag Free

O95750 (R23-K216)

9965  [NCBI]

RPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK

21-26 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Kir S, et al. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science. 2011 Mar 25;331(6024):1621-4.  [Content Brief]