FGF12 蛋白, Canine

FGF12 forms complexes with signaling proteins regulates the cytoskeletal system, binds to FGF receptors, activates signaling cascades to prevent apoptosis and interacts with ribosome biogenetic complexes. FGF12 has been linked to neurological diseases, cancer and heart disease, making it a potential target and therapeutic agent for gene therapy. FGF12 Protein, Canine is the recombinant canine-derived FGF12 protein, expressed by E. coli , with tag free. The total length of FGF12 Protein, Canine is 181 a.a., with molecular weight of ~20 kDa.

FGF 家族成员具有广泛的有丝分裂和细胞存活活性，并参与多种生物学过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。成纤维细胞生长因子 12 (FGF12) 属于成纤维细胞生长因子同源因子 (FHF) 亚家族，也称为 FGF11 亚家族。FGF12 是神经系统发育和功能的关键参与者，通过正向调节电压门控钠通道的活性来发挥其影响。FGF12 与信号蛋白形成复合物，调节细胞骨架系统，与 FGF 受体结合，激活信号级联以防止细胞凋亡，并与核糖体生物发生复合物相互作用。FGF12 与神经系统疾病、癌症和心脏病有关，成为基因治疗的潜在靶点和治疗剂。

Measured by its binding ability in a functional ELISA. Immobilized FGFR4 at 2 μg/mL (100 μL/well) can bind Biotinylated FGF-12. The ED₅₀ for this effect is 1.505 µg/mL.

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  Greater than 95% as determined by reducing SDS-PAGE.

Canine

E. coli

Tag Free

A0A5F4CAA4 (M1-T181)

478676  [NCBI]

MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST

Approximately 20 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.