Ficolin-1 蛋白, Human (HEK293, His)

IFN-β protein is a recombinant protein that does not use any animal-derived components in its production. It is used in biomedical research and drug manufacturing as a therapeutic agent for a variety of diseases, including multiple sclerosis. Ficolin-1 Protein, Human (HEK293, His) is the recombinant human-derived Ficolin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ficolin-1 Protein, Human (HEK293, His) is 297 a.a., with molecular weight of 33-38 kDa.

Ficolin-1 蛋白是 ficolin 家族的一员，其特征在于存在前导肽、短 N 末端片段、胶原蛋白样区域和 C 末端纤维蛋白原样结构域。这些结构元件与其他蛋白质（例如补体蛋白 C1q、集合素和生腱蛋白）共享，但该组中的每种蛋白质都能识别不同的靶标并发挥独特的功能。Ficolin-1 由 FCN1 编码，主要在外周血白细胞中表达，并被认为是具有弹性蛋白结合活性的血浆蛋白。值得注意的是，Ficolin-1 表现出偏向表达，在骨髓 (RPKM 318.5)、阑尾 (RPKM 117.5) 和其他三种组织中观察到水平升高，表明其在多种组织的各种生理环境中具有潜在意义。

Measured by its binding ability in a functional ELISA. Immobilized Fetuin at 10 μg/mL (100 μL/well) can bind Human Ficolin-1. The ED₅₀ for this effect is 1.49 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Fetuin at 10 μg/mL (100 μL/well) can bind Human Ficolin-1. The ED₅₀ for this effect is 1.49 μg/mL.

Human

HEK293

C-His

NP_001994.2 (A30-A326)

2219  [NCBI]

ADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA

33-38 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, 350 mM NaCl, 200 mM Arginine , pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.