2. 重组蛋白
  3. CAR-T related Proteins Receptor Proteins Biotinylated Proteins
  4. Folate Receptor alpha (FR-alpha)
  5. FOLR1 蛋白, Human (HEK293, His-Avi)

FOLR1 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78445
产品使用指南

FOLR1 蛋白是叶酸吸收的重要介质，与叶酸结合并促进 5-甲基四氢叶酸输送到细胞中。研究表明在中性 pH 值下具有高亲和力。内吞作用后，暴露于弱酸性 pH 值会引起构象变化，降低叶酸亲和力并促进释放。除了叶酸转运之外，FOLR1 对于胚胎发育和细胞增殖也至关重要，强调了它在基本细胞过程中的作用。FOLR1 蛋白, Human (HEK293, His-Avi) 是重组的 FOLR1 蛋白，由 HEK293 表达，带有 C-Avi, C-His 标签。FOLR1 蛋白, Human (HEK293, His-Avi) 全长 209 个氨基酸，分子量为 38-45 kDa。

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3.  试用装只面向终端客户。

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描述

FOLR1 protein is a vital mediator in folate uptake, binding to folate and facilitating the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. Upon endocytosis, exposure to a slightly acidic pH induces a conformational change, reducing folate affinity and facilitating release. Beyond folate transport, FOLR1 is crucial for embryonic development and cell proliferation, emphasizing its role in fundamental cellular processes. FOLR1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived FOLR1 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of FOLR1 Protein, Human (HEK293, His-Avi) is 209 a.a., with molecular weight of 38-45 kDa.
研究背景

FOLR1 蛋白作为叶酸摄取的关键介质，与叶酸和还原叶酸衍生物结合，促进 5-甲基四氢叶酸和叶酸类似物输送到细胞内部。各种研究证明，该过程的特点是在中性 pH 值下对叶酸和叶酸类似物具有高亲和力。值得注意的是，受体内吞作用后暴露于弱酸性 pH 值会引起构象变化，显着降低其对叶酸的亲和力，促进其释放。除了在叶酸转运中的作用之外，FOLR1 对于正常胚胎发育和适当的细胞增殖至关重要，强调了其在基本细胞过程中的重要性。
种属

Human
表达系统

HEK293
标签

C-Avi;C-His
蛋白编号

P15328 (R25-M233)
基因 ID
蛋白结构
N-term
FOLR1 (R25-M233)
Accession # P15328
His-Avi
C-term
同用名
FOLR; FOLR1; FBP; Folbp1; KB cells FBP; MOv18
分子量

38-45 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FOLR1 Protein, Human (HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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