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FOXM1 蛋白, Human (His, SUMO-Myc)

目录号: HY-P72197
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FOXM1 是一种重要的转录因子,控制对 DNA 复制和有丝分裂至关重要的细胞周期基因表达,强调了其在细胞过程中的关键作用。除了细胞增殖之外,FOXM1 还有助于 DNA 断裂修复和 DNA 损伤检查点反应。FOXM1 蛋白, Human (His, SUMO-Myc) 是重组的 FOXM1 蛋白,由 E. coli 表达,带有 N-10*His, C-Myc, N-SUMO 标签。FOXM1 蛋白, Human (His, SUMO-Myc) 全长 93 个氨基酸,分子量约为 ~31.2 kDa。

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描述

FOXM1 is an important transcription factor that controls cell cycle gene expression critical for DNA replication and mitosis, underscoring its critical role in cellular processes. In addition to cell proliferation, FOXM1 contributes to DNA break repair and DNA damage checkpoint responses. FOXM1 Protein, Human (His, SUMO-Myc) is the recombinant human-derived FOXM1 protein, expressed by E. coli , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of FOXM1 Protein, Human (His, SUMO-Myc) is 93 a.a., with molecular weight of ~31.2 kDa.

研究背景

FOXM1 是一种重要的转录因子,控制着对 DNA 复制和有丝分裂至关重要的细胞周期基因的表达,强调了其在协调细胞过程中的关键作用。除了参与细胞增殖控制之外,FOXM1 还有助于 DNA 断裂修复,积极参与 DNA 损伤检查点反应。值得注意的是,FOXM1 促进 PHB2 的转录,强调其多样化的调节功能。此外,FOXM1 与 PINT87aa 相互作用,PINT87aa 是由长非编码 RNA LINC-PINT 的环状形式编码的产物,这种相互作用可以抑制 FOXM1 介导的 PHB2 转录,揭示细胞转录过程中复杂的调控层。

种属

Human

表达系统

E. coli

标签

N-10*His;C-Myc;N-SUMO

蛋白编号

Q08050 (E235-L327)

基因 ID
蛋白结构
N-term
10*His
FOXM1 (E235-L327)
Accession # Q08050
Myc
C-term
同用名
FKHL16; Forkhead box M1; Forkhead box protein M1; forkhead like 16; Forkhead-related protein FKHL16; FOX M1; Foxm1; FOXM1_HUMAN; FOXM1B; HFH-11; HFH11; HNF-3/fork-head homolog 11; HNF3; INS1; M phase phosphoprotein 2; M-phase phosphoprotein 2; MPHOSPH2; MPP2; PIG29; TGT3; Transcription factor Trident; Trident; WIN; Winged-helix factor from INS1 cells
氨基酸序列

ERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPL

分子量

Approximately 31.2 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm sterile filtered 20 mM Tris-HCl,0.5 M NaCl, 6% Trehalose, pH 8.0

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料

FOXM1 Protein, Human (His, SUMO-Myc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FOXM1 Protein, Human (His, SUMO-Myc)
目录号:
HY-P72197
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