FSHR 蛋白, Human (His)

FSHR, a G protein-coupled receptor, specifically recognizes follitropin (FSH) and activates PI3K-AKT and ERK1/ERK2 pathways by promoting cAMP production. Operating as a homotrimer, FSHR binds the heterodimeric FSH hormone, forming a functional unit for signal transduction. Its regulatory mechanisms involve interaction with ARRB2, and independently of FSH stimulation, it engages with APPL2, demonstrating versatility in diverse cellular contexts. FSHR Protein, Human (His) is the recombinant human-derived FSHR protein, expressed by E. coli , with N-6*His labeled tag. The total length of FSHR Protein, Human (His) is 349 a.a., with molecular weight of 47-51 kDa.

FSHR 是一种 G 蛋白偶联受体，专门用于识别促卵泡激素（也称为促卵泡激素）。该受体通过促进 cAMP 产生来激活下游信号传导通路，包括 PI3K-AKT 和 ERK1/ERK2 通路。作为同源三聚体，FSHR 与由 CGA 和 FSHB 亚基组成的异二聚体 FSH 激素结合，形成信号转导的功能单元。FSHR 与 ARRB2 的相互作用有助于其调节机制，并且它还独立于卵泡刺激激素刺激而与 APPL2 结合，展示了其在不同细胞环境中的多功能性。

Immobilized Human FSH at 2 μg/mL (100 μL/well) can bind Human FSHR. The ED₅₀ for this effect is 0.265 μg/mL.

Human

E. coli

N-6*His

P23945 (C18-R366)

2492  [NCBI]

CHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILR

47-51 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.