GAS6 蛋白, Mouse (674a.a, HEK293, His)

GAS6 Protein is a vitamin K-dependent protein involved in signaling pathways including GAS6/AXL. The GAS6 Protein contains an NH₂ terminal Gla domain as well as four EGF-like repeats and tandem gl bular domains. GAS6 Protein, Mouse (674a.a, HEK293, His) is the recombinant mouse-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag. The total length of GAS6 Protein, Mouse (674a.a, HEK293, His) is 674 a.a., with molecular weight of ~73.5 kDa.

Growth arrest-specific protein 6 (GAS6) 是一种维生素 K 依赖性蛋白，与天然抗凝蛋白 S 具有高度的结构同源性，具有相同的模块组成和 40% 的序列同源性。GAS6 包含一个 NH₂ 末端 Gla 结构域以及四个表皮生长因子样重复序列和串联球状结构域。GAS6 是酪氨酸-蛋白激酶受体 AXL, TYRO3 和 MER 的配体，其信号传导涉及细胞生长和存活，细胞粘附和细胞迁移。GAS6/AXL 信号在多种过程中发挥作用，如酸化过程中内皮细胞的存活，通过防止细胞凋亡，人类自然杀伤细胞发育过程中的最佳细胞因子信号，肝脏再生，促性腺激素释放激素神经元的存活和迁移，血小板活化或血栓反应的调节。

Mouse

HEK293

C-His

Q61592 (M1-P674)

14456  [NCBI]

MPPPPGPAAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQECMRKYGRPEEKNPDFAKCVQNLPDQCTPNPCDKKGTHICQDLMGNFFCVCTDGWGGRLCDKDVNECVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTCQDIDECTDSDTCGDARCKNLPGSYSCLCDEGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCDGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLERGLYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFATYRLNYTRTSLDVGTETTWEVKVVARIRPATDTGVLLALVGDDDVVPISVALVDYHSTKKLKKQLVVLAVEDVALALMEIKVCDSQEHTVTVSLREGEATLEVDGTKGQSEVSTAQLQERLDTLKTHLQGSVHTYVGGLPEVSVISAPVTAFYRGCMTLEVNGKILDLDTASYKHSDITSHSCPPVEHATP

Approximately 73.5 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.