2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Bone Morphogenetic Proteins (BMPs)
  6. BMP-11/GDF-11
  7. GDF-11/BMP-11 蛋白, Human (HEK293, solution)

GDF-11/BMP-11 蛋白, Human (HEK293, solution)

目录号: HY-P70222Y
COA 产品使用指南

GDF-11/BMP-11 蛋白是一种分泌信号蛋白，在发育过程中全局调节前/后轴模式，并在中胚层和神经组织模式中发挥关键作用。GDF-11/BMP-11 对于椎骨和口面部发育至关重要，并通过 2 型激活素受体（ACVR2A 和 ACVR2B）和 1 型激活素受体（ACVR1B、ACVR1C 和 TGFBR1）发出信号，导致 SMAD2 和 SMAD3 磷酸化。GDF-11/BMP-11 蛋白, Human (HEK293, solution) 是重组的 GDF-11/BMP-11 蛋白，由 HEK293 表达，不带标签。GDF-11/BMP-11 蛋白, Human (HEK293, solution) 全长 109 个氨基酸，分子量约为 ~14.0 kDa。

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 μg ￥1550 In-stock
50 μg ￥4300 In-stock
100 μg   询价  

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描述

The GDF-11/BMP-11 protein is a secreted signaling protein that globally regulates anterior/posterior axis patterning during development and plays a key role in mesoderm and neural tissue patterning. GDF-11/BMP-11 is critical for vertebral and orofacial development and signals through type 2 activin receptors (ACVR2A and ACVR2B) and type 1 activin receptors (ACVR1B, ACVR1C and TGFBR1), leading to SMAD2 and SMAD3 phosphorylation. GDF-11/BMP-11 Protein, Human (HEK293, solution) is the recombinant human-derived GDF-11/BMP-11 protein, expressed by HEK293 , with tag free. The total length of GDF-11/BMP-11 Protein, Human (HEK293, solution) is 109 a.a., with molecular weight of ~14.0 kDa.
研究背景

GDF-11/BMP-11 是一种分泌信号蛋白，对发育过程中的前/后轴模式具有全局调节影响，并且在中胚层和神经组织模式中发挥关键作用。GDF-11/BMP-11 对于椎骨和口面部的正常发育至关重要，它通过 2 型激活素受体（ACVR2A 和 ACVR2B）和 1 型激活素受体（ACVR1B、ACVR1C 和 TGFBR1）传递信号，导致 SMAD2 和 TGFBR1 的磷酸化。SMAD3。该蛋白通过二硫键形成同二聚体，并直接与 ACVR2A、ACVR2B、ACVR1B、TGFBR1 和 ACVR1C 相互作用，后者以 ACVR2B 依赖性方式相互作用。此外，GDF-11/BMP-11 与 FST 同工型 2/FS-288 结合，突显其与信号通路中关键受体的复杂相互作用。
种属

Human
表达系统

HEK293
标签

Tag Free
蛋白编号

O95390 (N299-S407)
基因 ID
蛋白结构
N-term
BMP-11 (N299-S407)
Accession # O95390
C-term
同用名
rHuGrowth/differentiation factor 11; Growth/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11
氨基酸序列

NLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS

分子量

Approximately 14.0 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
性状

溶液
组分

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4.
内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

N/A.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
运输条件

Shipping with dry ice.
文件资料

COA (209 KB)

产品使用指南 (1213 KB)

GDF-11/BMP-11 Protein, Human (HEK293, solution) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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