GFAP 蛋白, Mouse (His-SUMO)

The GFAP protein is a member of the class III intermediate filament family and serves as a cell-specific marker critical for distinguishing astrocytes from other glial cells in the developing central nervous system. Its role as a marker is critical in defining the identity of astrocytes, highlighting their unique characteristics in a complex cellular environment. GFAP Protein, Mouse (His-SUMO) is the recombinant mouse-derived GFAP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of GFAP Protein, Mouse (His-SUMO) is 430 a.a., with molecular weight of ~65.9 kDa.

胶质纤维酸性蛋白 (GFAP) 被归类为 III 类中间丝，作为细胞特异性标记物，对于区分星形胶质细胞与其他胶质细胞至关重要，特别是在中枢神经系统的发育过程中。GFAP 在星形胶质细胞细胞骨架的形成和维持中发挥着关键作用，有助于其结构支撑和稳定性。它的表达对星形胶质细胞具有高度特异性，使其成为在各种生理和病理情况下识别这些神经胶质细胞的有价值的标记。此外，据报道 GFAP 与 SYNM 相互作用，表明与星形胶质细胞内参与细胞骨架动力学或细胞信号传导途径的蛋白质存在潜在的功能关联。这种相互作用为理解 GFAP 在星形胶质细胞生物学中的作用增加了一层复杂性。正在进行的研究可能会揭示有关 GFAP 在中枢神经系统中的分子机制和功能影响的更多细节。

Mouse

E. coli

N-6*His;N-SUMO

P03995 (M1-M430)

14580  [NCBI]

MERRRITSARRSYASETVVRGLGPSRQLGTMPRFSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNFAQDLGTLRQKLQDETNLRLEAENNLAAYRQEADEATLARVDLERKVESLEEEIQFLRKIYEEEVRELREQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDAASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKDSKQEHKDVVM

Approximately 65.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.