1. 重组蛋白
  2. Receptor Proteins
  3. G-Protein-Coupled Receptors (GPCRs)
  4. GIPR 蛋白, Human (HEK293, His, Avi)

GIPR 蛋白, Human (HEK293, His, Avi)

目录号: HY-P703991
产品使用指南 技术支持

GIPR 蛋白是葡萄糖依赖性促胰岛素多肽 (GIP) 的受体,通过激活腺苷酸环化酶的 G 蛋白发挥作用。它与 GLP1R 形成同二聚体和异二聚体的能力意味着与肠促胰岛素激素相关的受体之间存在潜在的相互作用。GIPR 蛋白, Human (HEK293, His, Avi) 是重组的 GIPR 蛋白,由 HEK293 表达,带有 C-Avi 和 C-His 标签。

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描述

GIPR protein, a receptor for glucose-dependent insulinotropic polypeptide (GIP), operates through G proteins that activate adenylyl cyclase. Its capacity for homodimer and heterodimer formation with GLP1R implies potential interactions between receptors linked to incretin hormones. GIPR Protein, Human (HEK293, His, Avi) is the recombinant human-derived GIPR protein, expressed by HEK293, with C-Avi and C-His labeled tag.

研究背景

GIPR 蛋白作为葡萄糖依赖性促胰岛素多肽 (GIP) 的受体发挥作用。其活性由 G 蛋白介导,特别是那些激活腺苷酸环化酶的蛋白。值得注意的是,GIPR 有可能与 GLP1R 形成同二聚体和异二聚体,这表明与肠促胰岛素激素相关的受体之间可能存在相互作用。

种属

Human

表达系统

HEK293

标签

C-Avi;C-8*His

蛋白编号

P48546-1 (G26-Q138)

基因 ID

2696

蛋白结构
N-term
GIPR (G26-Q138)
Accession # P48546-1
8*His-Avi
C-term
蛋白长度

Extracellular Domain

中文名
GIPR 蛋白
同用名
GIP-R; GIPR; PGQTL2
预测分子量
15.9 kDa
分子量

Approximately 30-40 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

糖基化修饰
Yes
纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

GIPR Protein, Human (HEK293, His, Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
GIPR Protein, Human (HEK293, His, Avi)
目录号:
HY-P703991
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