1. 重组蛋白
  2. Cytokines and Growth Factors GMP-grade Proteins
  3. GMP FLT3LG 蛋白, Human (HEK293, His)

GMP FLT3LG 蛋白, Human (HEK293, His)

目录号: HY-P70544G
COA 产品使用指南

FLT3LG Proteinas 是一种早期造血细胞增殖的有效刺激剂,可激活 FLT3 并与集落刺激因子和白细胞介素产生协同作用。作为同型二聚体,尤其是同工型 2,它对促进造血祖细胞的扩增和分化至关重要。FLT3LG 与其他分子的协同信号强调了其在调节造血和维持造血系统平衡方面的重要性。GMP FLT3LG 蛋白, Human (HEK293, His) 是重组的 GMP 级别 FLT3LG 蛋白,由 HEK293 表达,带有 C-6*His 标签。GMP FLT3LG 蛋白, Human (HEK293, His) 全长 158 个氨基酸,分子量为 24-32 kDa。

GMP 级别 (GMP-grade) 重组蛋白是在独立的 QA 监督下生产,并具有质量记录和完全可追溯性。

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规格 价格 是否有货 数量
50 μg ¥6000 In-stock
100 μg   询价  

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描述

FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. GMP FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP FLT3LG Protein, Human (HEK293, His) is 158 a.a., with molecular weight of 24-32 kDa.

研究背景

FLT3LG 蛋白通过激活 FLT3 作为早期造血细胞增殖的有效刺激剂,与各种集落刺激因子和白细胞介素结合时显示出协同效应。这种同型二聚体蛋白,尤其是亚型 2,在促进造血祖细胞的扩增和分化中发挥着至关重要的作用。它激活FLT3并与其他信号分子协作的能力强调了其在调节造血和维持造血系统平衡方面的重要性。

生物活性

Immobilized Human Flt-3 Ligand at 5 μg/mL (100 μL/well) can bind Human FLT3 (C-Fc).The specific activity is >1×106 U/mg.

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

P49771 (T27-P184)

基因 ID
蛋白结构
N-term
GMP FLT3LG (T27-P184)
Accession # P49771
6*His
C-term
同用名
Fms-related tyrosine kinase 3 ligand; Flt3L; SL cytokine; FLT3LG
氨基酸序列

TQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPTAPQP

分子量

24-32kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

内毒素含量

<0.05 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

GMP FLT3LG Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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GMP FLT3LG Protein, Human (HEK293, His)
目录号:
HY-P70544G
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