2. 重组蛋白
  3. Cytokines and Growth Factors
  4. HGF & Receptors
  5. HGF
  6. GMP HGF 蛋白, Human (HEK293, His)

GMP HGF 蛋白, Human (HEK293, His)

目录号: HY-P70627G
产品使用指南

HGF 蛋白是一种有效的有丝分裂原，可刺激成熟肝细胞生长并表现出保肝特性。它作为多种组织的生长因子，作为 MET 受体酪氨酸激酶的激活配体。结合后，HGF 促进 MET 二聚化，通过 TMPRSS13 裂解激活 MAPK 信号级联。在结构上，HGF 包含通过二硫键连接的 α 链和 β 链。与 SRPX2 的相互作用增强其促有丝分裂活性。GMP HGF 蛋白, Human (HEK293, His) 是重组的 GMP 级别 HGF 蛋白，由 HEK293 表达，带有 C-6*His 标签。GMP HGF 蛋白, Human (HEK293, His) 全长 697 个氨基酸，分子量分别为 32-38 & 50-65 kDa。

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3.  试用装只面向终端客户。

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描述

HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and exhibits hepatotrophic properties. It acts as a growth factor for diverse tissues, functioning as an activating ligand for MET receptor tyrosine kinase. Upon binding, HGF promotes MET dimerization, activating the MAPK signaling cascade via TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains linked by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. GMP HGF Protein, Human (HEK293, His) is the recombinant human-derived HGF protein, expressed by HEK293, with C-6*His labeled tag. The total length of GMP HGF Protein, Human (HEK293, His) is 697 a.a., with molecular weight of 32-38 & 50-65 kDa, respectively.
研究背景

HGF 蛋白是一种有效的有丝分裂原，可刺激成熟肝实质细胞的生长并表现出保肝特性。它还充当各种组织和细胞类型的生长因子。HGF 蛋白作为受体酪氨酸激酶 MET 的激活配体，在结合后促进其二聚化。这反过来又在 TMPRSS13 裂解和激活后激活 MAPK 信号级联。在结构上，HGF 蛋白由通过二硫键连接在一起的 α 链和 β 链组成。此外，HGF 蛋白与 SRPX2 相互作用，导致促有丝分裂活性增加。
种属

Human
表达系统

HEK293
标签

C-6*His
蛋白编号

P14210(Q32-S728)
基因 ID

3082
蛋白结构
N-term
HGF (Q32-S728)
Accession # P14210
6*His
C-term
同用名
Hepatocyte growth factor; HPTA; HGF; SF; Scatter factor; Hepatopoietin-A
氨基酸序列

QRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS

分子量

32-38 &50-65 KDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<10 EU/mg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GMP HGF Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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