GSTP1 蛋白, Human (His)

The GSTP1 protein is critical for binding reduced glutathione to a variety of hydrophobic electrophiles, actively forming glutathione conjugates of PGA2 and PGJ2. Documented studies highlight its involvement in hepoxilin regioisomer synthesis, emphasizing the versatility of GSTP1 in processing substrates. GSTP1 Protein, Human (His) is the recombinant human-derived GSTP1 protein, expressed by E. coli , with N-10*His labeled tag. The total length of GSTP1 Protein, Human (His) is 209 a.a., with molecular weight of ~25 kDa.

GSTP1 蛋白在还原型谷胱甘肽与各种外源和内源疏水性亲电子试剂结合的细胞过程中发挥着至关重要的作用。具体而言，正如研究记录的那样，GSTP1 积极参与前列腺素 A2 (PGA2) 和前列腺素 J2 (PGJ2) 谷胱甘肽缀合物的形成。此外，GSTP1 参与新型 hepoxilin 区域异构体的合成，强调了其在处理各种底物方面的多功能性。除了解毒作用外，GSTP1 还通过促进 p25/p35 易位来负向调节 CDK5 活性，成为预防神经退行性变的关键机制。

Human

E. coli

N-10*His

P09211 (P2-Q210)

2950  [NCBI]

PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ

Approximately 25 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.