H2AC4 蛋白, Human

The H2AC4 protein is a core component of nucleosomes, which compress DNA into chromatin and restrict DNA entry into cellular processes. H2AC4 Protein, Human is the recombinant human-derived H2AC4 protein, expressed by E. coli , with tag free.

H2AC4 蛋白是核小体的核心成分，核小体是一种将 DNA 包裹并压缩到染色质中的整体结构，有效限制 DNA 接触需要 DNA 作为模板的细胞机器。包括 H2AC4 在内的组蛋白在转录调控、DNA 修复、DNA 复制和维持染色体稳定性等关键细胞过程中发挥着关键作用。DNA 可及性的复杂调控涉及复杂的翻译后修饰网络（统称为组蛋白密码）和动态核小体重塑。核小体本身包含组蛋白八聚体，由 H2A、H2B、H3 和 H4 各两个分子组成，排列成一个 H3-H4 异四聚体和两个 H2A-H2B 异二聚体。这种八聚体有效地包裹了大约 147 个碱基对的 DNA，强调了它在组织染色质结构和促进基因组功能中的基本作用。

Human

E. coli

Tag Free

P04908 (S2-K130)

3012  [NCBI]

Full Length of Mature Protein

SGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

Approximately 14.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of ddH₂O, pH 7.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.