HB-EGF 蛋白, Human (HEK293, His)

HB-EGF protein is a multifunctional growth factor that is regulated through EGFR, ERBB2 and ERBB4 and is critical for cardiac valve formation and cardiac function. It promotes smooth muscle cell proliferation and may contribute to macrophage-mediated cell proliferation. HB-EGF Protein, Human (HEK293, His) is the recombinant human-derived HB-EGF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HB-EGF Protein, Human (HEK293, His) is 129 a.a., with molecular weight of ~18 kDa.

HB-EGF蛋白是一种多功能生长因子，通过EGFR、ERBB2和ERBB4发挥其调节作用。HB-EGF 对于心脏瓣膜形成和正常心脏功能至关重要，在促进平滑肌细胞增殖方面发挥着关键作用，并可能有助于巨噬细胞介导的细胞增殖。HB-EGF 对成纤维细胞具有促有丝分裂特性，同时不影响内皮细胞，其独特之处在于它与 EGF 受体/EGFR 的结合比 EGF 具有更大的亲和力，成为平滑肌细胞更有效的有丝分裂原。除了其增殖作用之外，HB-EGF 还充当白喉毒素受体并与 FBLN1 相互作用。HB-EGF 与 EGFR 和 ERBB4 的多方面相互作用强调了其在细胞调节和心血管发育中的核心作用。

Human

HEK293

C-6*His

Q99075 (L20-L148)

1839  [NCBI]

LVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSL

Approximately 18 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.