2. 重组蛋白
  3. Enzymes & Regulators
  4. Oxidoreductases (EC 1)
  5. HCDH 蛋白, Mouse (His-SUMO)

HCDH 蛋白, Mouse (His-SUMO)

目录号: HY-P71563
产品使用指南

HCDH 蛋白是线粒体脂肪酸 β-氧化的关键，负责管理中链和短链 3-羟基脂肪酰基辅酶 A（C4 至 C10）的第三步。除了脂质代谢之外，HCDH 通过抑制谷氨酸脱氢酶 1 (GLUD1) 激活（氨基酸诱导的胰岛素分泌中的关键酶）来调节胰岛素分泌。HCDH 是调节与能量代谢和葡萄糖稳态相关的细胞过程的关键因素。HCDH 蛋白, Mouse (His-SUMO) 是重组的 HCDH 蛋白，由 E. coli 表达，带有 N-His, N-SUMO 标签。HCDH 蛋白, Mouse (His-SUMO) 全长 302 个氨基酸，分子量约为 ~49.0 kDa。

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描述

HCDH Protein, pivotal in mitochondrial fatty acid beta-oxidation, manages the third step for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Beyond lipid metabolism, HCDH regulates insulin secretion by inhibiting glutamate dehydrogenase 1 (GLUD1) activation, a key enzyme in amino acid-induced insulin secretion. HCDH emerges as a pivotal factor in regulating cellular processes related to energy metabolism and glucose homeostasis. HCDH Protein, Mouse (His-SUMO) is the recombinant mouse-derived HCDH protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of HCDH Protein, Mouse (His-SUMO) is 302 a.a., with molecular weight of ~49.0 kDa.
研究背景

HCDH 蛋白是线粒体脂肪酸 β 氧化的关键参与者，专门针对从 C4 到 C10 的中链和短链 3-羟基脂肪酰基辅酶 A 协调 β 氧化循环的第三步。除了在脂质代谢中的作用外，HCDH 还通过阻止谷氨酸脱氢酶 1 (GLUD1) 的激活来对胰岛素分泌进行调节。GLUD1 是氨基酸诱导的胰岛素分泌中的关键酶，对 GLUD1 的抑制使 HCDH 成为与能量代谢和葡萄糖稳态相关的细胞过程的复杂调节中的关键因素。
种属

Mouse
表达系统

E. coli
标签

N-His;N-SUMO
蛋白编号

Q61425 (13S-314K)
基因 ID

15107  [NCBI]
蛋白结构
N-term
6*His-SUMO
HCDH (13S-314K)
Accession # Q61425
C-term
同用名
Hadh; Hadhsc; Mschad; Schad; Hydroxyacyl-coenzyme A dehydrogenase; mitochondrial; HCDH; EC 1.1.1.35; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase
氨基酸序列

SSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK

分子量

Approximately 49.0 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

HCDH Protein, Mouse (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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