1. 重组蛋白
  2. Viral Proteins
  3. Influenza Viruses Proteins
  4. Influenza Hemagglutinin
  5. Hemagglutinin/HA 蛋白, H14N5 (P26136, sf9, His)

Hemagglutinin/HA 蛋白, H14N5 (P26136, sf9, His)

目录号: HY-P77020
产品使用指南

HA1/血凝素蛋白结合细胞表面受体,促进病毒附着。它决定宿主范围和毒力,介导病毒和内体膜的融合。酸性内体触发 HA2 构象变化,释放融合肽。多个HA1三聚体形成融合孔。Hemagglutinin/HA 蛋白, H14N5 (P26136, sf9, His) 是重组的 血凝素/HA 蛋白,由 Sf9 昆虫细胞表达,带有 C-His 标签。Hemagglutinin/HA 蛋白, H14N5 (P26136, sf9, His) 全长 531 个氨基酸,分子量约为 ~58.6 KDa。

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描述

The HA1/Hemagglutinin protein binds cell surface receptors, facilitating virus attachment. It determines host range and virulence, mediating fusion of viral and endosomal membranes. Acidic endosomes trigger HA2 conformational change, releasing fusion peptide. Multiple HA1 trimers form fusion pore. Hemagglutinin/HA Protein, H14N5 (P26136, sf9, His) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of Hemagglutinin/HA Protein, H14N5 (P26136, sf9, His) is 531 a.a., with molecular weight of ~58.6 KDa.

研究背景

HA1/血凝素蛋白与细胞表面含有唾液酸的受体结合,促进病毒颗粒附着到细胞上。这种附着导致大约三分之二的病毒颗粒通过称为网格蛋白依赖性内吞作用的过程内化,而大约三分之一通过网格蛋白和小窝蛋白独立途径进入。HA1蛋白在决定病毒的宿主范围限制和毒力方面发挥着至关重要的作用。作为I类病毒融合蛋白,它通过介导病毒膜与内体膜的融合使病毒能够穿透细胞质。内体中的酸性环境会触发 HA2 亚基发生不可逆的构象变化,导致融合所需的疏水性肽的释放。有效融合孔的形成需要 HA1/血凝素蛋白的多个三聚体的存在。

种属

Virus

表达系统

Sf9 insect cells

标签

C-His

蛋白编号

P26136 (M1-D531)

基因 ID

/

蛋白结构
N-term
H14N5 HA (M1-D531)
Accession # P26136
His
C-term
同用名
Influenza A H14N5 (A/mallard/Astrakhan/263/1982) Hemagglutinin / HA Protein (His)
分子量

Approximately 58.6 kDa.

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Hemagglutinin/HA Protein, H14N5 (P26136, sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Hemagglutinin/HA Protein, H14N5 (P26136, sf9, His)
目录号:
HY-P77020
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