2. 重组蛋白
  3. Viral Proteins
  4. Influenza Viruses Proteins
  5. Influenza Hemagglutinin
  6. Hemagglutinin/HA 蛋白, H6N4 (CAC84244, sf9, His)

Hemagglutinin/HA 蛋白, H6N4 (CAC84244, sf9, His)

目录号: HY-P77031
产品使用指南

血凝素/HA 蛋白附着在唾液酸受体上，启动病毒与细胞的结合。这种附着促进病毒粒子通过网格蛋白依赖性或非依赖性途径内化。HA 对于确定病毒宿主范围和毒力至关重要。作为 I 类病毒融合蛋白，它通过介导内吞病毒颗粒膜与内体膜之间的融合来促进病毒进入细胞质。在内体的低pH值下，HA2经历不可逆的构象变化，释放融合疏水肽。多个 HA 三聚体对于形成有能力的融合孔至关重要。Hemagglutinin/HA 蛋白, H6N4 (CAC84244, sf9, His) 是重组的 血凝素/HA 蛋白，由 Sf9 昆虫细胞表达，带有 C-His 标签。Hemagglutinin/HA 蛋白, H6N4 (CAC84244, sf9, His) 全长 529 个氨基酸，分子量约为 ~52.6 KDa。

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描述

Hemagglutinin/HA protein attaches to sialic acid receptors, initiating virus binding to cells. This attachment prompts virion internalization via clathrin-dependent or -independent pathways. HA is pivotal in determining virus host range and virulence. As a Class I viral fusion protein, it facilitates virus entry into the cell cytoplasm by mediating fusion between the endocytosed virus particle's membrane and the endosomal membrane. In endosomes' low pH, HA2 undergoes an irreversible conformational change, releasing the fusion hydrophobic peptide. Multiple HA trimers are essential for forming a competent fusion pore. Hemagglutinin/HA Protein, H6N4 (CAC84244, sf9, His) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of Hemagglutinin/HA Protein, H6N4 (CAC84244, sf9, His) is 529 a.a., with molecular weight of ~52.6 KDa.
研究背景

血凝素/HA 蛋白与细胞表面上含唾液酸的受体结合，导致病毒颗粒附着在细胞上。这种附着可以通过网格蛋白依赖性内吞作用或网格蛋白和小窝蛋白独立途径触发病毒颗粒内化。HA蛋白在决定病毒的宿主范围限制和毒力方面发挥着至关重要的作用。作为I类病毒融合蛋白，它负责通过介导内吞病毒颗粒膜与内体膜之间的融合来促进病毒渗透到细胞质中。在内体的低pH环境下，HA2发生不可逆的构象变化，导致融合疏水肽的释放。需要多个HA三聚体才能形成有能力的融合孔。
种属

Virus
表达系统

Sf9 insect cells
标签

C-His
蛋白编号

Q8UWX0 (M1-Q529)
基因 ID

/
蛋白结构
N-term
H6N4 HA (M1-Q529)
Accession # Q8UWX0
His
C-term
同用名
Influenza A H6N4 (A/chicken/Hong Kong/17/1977) Hemagglutinin / HA Protein (His)
分子量

Approximately 52.6 kDa.
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Hemagglutinin/HA Protein, H6N4 (CAC84244, sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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