HER2/CD340 蛋白, Cynomolgus (HEK293, hFc)

HER2/CD340 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived HER2/CD340 protein, expressed by HEK293, with C-hFc tag.

ErbB 家族由四个单独的质膜结合受体酪氨酸激酶组成。其中一个是 erbB-2，其他成员是 erbB-1, erbB-3 (神经调节蛋白结合;缺乏激酶结构域) 和 erbB-4。受体酪氨酸蛋白激酶 erbB-2 是一种通常存在于细胞膜上的蛋白，由 ERBB2 基因编码。人蛋白也经常被称为 HER 2 (人表皮生长因子受体 2) 或 CD340 (分化簇340)。HER2 与 Hsp90 蛋白、蛋白酪氨酸激酶和泛素化蛋白有结合活性。ErbB2 通过 PI3K/Akt 通路调控耳蜗核神经干细胞的分化和凋亡。HER2 是一种在膀胱癌中过表达的致癌因子，可激活致癌信号通路，从而促进肿瘤细胞的存活/增殖。

Cynomolgus

HEK293

C-hFc

XP_005584091.2 (T23-T652)

102146608

Approximately 120-150 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.