1. 重组蛋白
  2. Cytokines and Growth Factors CAR-T related Proteins CD Antigens Receptor Proteins Enzymes & Regulators
  3. EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. ErbB2/CD340 EGFR/ErbB family
  5. HER2/CD340 蛋白, Mouse (HEK293, His)

HER2/CD340 蛋白, Mouse (HEK293, His)

目录号: HY-P73929
COA 产品使用指南

HER2/CD340 蛋白是一种多功能酪氨酸激酶,是神经调节蛋白受体复合物的组成部分,可调节微管动力学。激活的 HER2/CD340 触发 MEMO1-RHOA-DIAPH1 通路,抑制细胞膜上的 GSK3B,并促进 APC 和 CLASP2 的结合,这对于微管的稳定性至关重要。HER2/CD340 蛋白, Mouse (HEK293, His) 是重组的 HER2/CD340 蛋白,由 HEK293 表达,带有 C-His 标签。HER2/CD340 蛋白, Mouse (HEK293, His) 全长 631 个氨基酸,分子量为 100-110 kDa。

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描述

The HER2/CD340 protein is a multifunctional tyrosine kinase that is a component of the neuregulin receptor complex and regulates microtubule dynamics. Activated HER2/CD340 triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B on the cell membrane and promotes the binding of APC and CLASP2, which is critical for microtubule stability. HER2/CD340 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HER2/CD340 protein, expressed by HEK293 , with C-His labeled tag. The total length of HER2/CD340 Protein, Mouse (HEK293, His) is 631 a.a., with molecular weight of 100-110 kDa.

研究背景

HER2/CD340 蛋白是一种多面蛋白酪氨酸激酶,是各种细胞表面受体复合物的重要组成部分,需要辅助受体来进行配体结合。它是神经调节蛋白-受体复合物的组成部分,与神经调节蛋白协同作用,并且 GP30 成为该受体的潜在配体。除了其受体作用之外,HER2/CD340 在调节外周微管 (MT) 的生长和稳定方面也发挥着关键作用。激活后,由 ERBB2 激活触发的 MEMO1-RHOA-DIAPH1 信号通路会导致 GSK3B 磷酸化并随后在细胞膜上受到抑制。这种精心策划的抑制可防止 APC 和 CLASP2 的磷酸化,促进它们与细胞膜的结合。膜结合的 APC 反过来又促进 MACF1 定位到细胞膜,这是微管捕获和稳定的关键步骤。在细胞核内,HER2/CD340 参与转录调控,与 PTGS2/COX-2 启动子中的 5'-TCAATTC-3' 序列结合并激活其转录。此外,它还通过 RNA Pol I 参与 rRNA 基因的转录,增强蛋白质合成并促进细胞生长。HER2/CD340 的多方面功能强调了其在多种细胞过程中的核心作用,从受体信号传导到微管动力学和转录调节。

生物活性

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

P70424 (T23-T653)

基因 ID
蛋白结构
N-term
HER2 (T23-T653)
Accession # P70424
His
C-term
中文名
重组鼠HER2蛋白
同用名
Receptor tyrosine-protein kinase erbB-2; MLN 19; CD340; ERBB2; HER2; NEU; NGL
氨基酸序列

TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVT

分子量

100-110 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HER2/CD340 Protein, Mouse (HEK293, His)
目录号:
HY-P73929
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