2. 重组蛋白
  3. Cytokines and Growth Factors CAR-T related Proteins CD Antigens Receptor Proteins Enzymes & Regulators
  4. EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. ErbB2/CD340 EGFR/ErbB family
  6. HER2/CD340 蛋白, Rat (HEK293)

HER2/CD340 蛋白, Rat (HEK293)

目录号: HY-P73097
产品使用指南

HER2/CD340 蛋白是受体酪氨酸激酶家族的成员。HER2/CD340蛋白参与PI3K/Akt信号通路调节耳蜗核内神经干细胞的分化和凋亡。HER2/CD340 蛋白是膀胱癌中过度表达的致癌因子，可激活致癌信号通路，从而促进肿瘤细胞存活/增殖。HER2/CD340 蛋白, Rat (HEK293) 是重组的 HER2/CD340 蛋白，由 HEK293 表达，不带标签。HER2/CD340 蛋白, Rat (HEK293) 全长 653 个氨基酸，分子量为 95-105 kDa。

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描述

The HER2/CD340 Protein is a member of the receptor tyrosine kinase family. HER2/CD340 Protein participates in the PI3K/Akt signaling pathway to regulate the differentiation and apoptosis of neural stem cells in the cochlear nucleus. HER2/CD340 Protein is an overexpressed oncogenic factor in bladder cancer that activates the oncogenic signaling pathway, thereby promoting tumor cell survival/proliferation. HER2/CD340 Protein, Rat (HEK293) is the recombinant rat-derived HER2/CD340 protein, expressed by HEK293, with tag free. The total length of HER2/CD340 Protein, Rat (HEK293) is 653 a.a., with molecular weight of 95-105 kDa.
研究背景

ErbB 家族由四种独立的质膜结合受体酪氨酸激酶组成。其中之一是 erbB-2，其他成员是 erbB-1、erbB-3（神经调节蛋白结合；缺乏激酶结构域）和 erbB-4。受体酪氨酸蛋白激酶 erbB-2 是一种通常存在于细胞膜上的蛋白质，由 ERBB2 基因编码。人类蛋白质通常也称为 HER 2（人类表皮生长因子受体 2）或 CD340（分化簇 340）。HER2与Hsp90蛋白、蛋白酪氨酸激酶和泛素化蛋白具有结合活性。ErbB2通过PI3K/Akt途径调节耳蜗核内神经干细胞的分化和凋亡。HER2 是一种致癌因子，在膀胱癌中过度表达并激活致癌信号通路，从而促进肿瘤细胞存活/增殖[1][2][3 ][4]。
种属

Rat
表达系统

HEK293
标签

Tag Free
蛋白编号

Q8K3F9 (M4-T656)
基因 ID
蛋白结构
N-term
HER2 (M4-T656)
Accession # Q8K3F9
C-term
同用名
Receptor tyrosine-protein kinase erbB-2; MLN 19; CD340; ERBB2; HER2; NEU; NGL
氨基酸序列

MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDCGLEGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVT

分子量

95-105 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

HER2/CD340 Protein, Rat (HEK293) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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