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  5. HER3 蛋白, Rhesus Macaque (HEK293, Fc)

HER3 蛋白, Rhesus Macaque (HEK293, Fc)

目录号: HY-P76968
COA 产品使用指南

HER3 是一种关键的酪氨酸蛋白激酶,是神经调节蛋白的重要细胞受体。Neuregulin-1 (NRG1) 激活可促进酪氨酸磷酸化以及与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。CSPG5 也可能激活 HER3。它参与骨髓细胞分化,强调了 HER3 在正常发育和功能的重要细胞过程中的重要作用。HER3 蛋白, Rhesus Macaque (HEK293, Fc) 是重组的 HER3 蛋白,由 HEK293 表达,带有 C-hFc 标签。HER3 蛋白, Rhesus Macaque (HEK293, Fc) 全长 624 个氨基酸,分子量为 130-140 kDa。

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规格 价格 是否有货 数量
20 μg ¥1900 In-stock
50 μg ¥4200 询价
100 μg   询价  

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描述

HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HER3 Protein, Rhesus Macaque (HEK293, Fc) is 624 a.a., with molecular weight of 130-140 kDa.

研究背景

HER3 是一种酪氨酸蛋白激酶,是神经调节蛋白的关键细胞表面受体。由神经调节蛋白-1 (NRG1) 激活,配体结合增强酪氨酸残基的磷酸化,并促进其与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。此外,有证据表明 CSPG5 可以激活。HER3 错综复杂地参与骨髓细胞分化的调节,突出了其在对正常发育和功能至关重要的细胞过程中的关键作用。

生物活性

Measured by its binding ability in a functional ELISA. Immobilized Human NRG1 Alpha His at 2 μg/mL (100 μl/well) can bind Rhesus HER3/ERBB3 hFc, the EC50 of Rhesus HER3/ERBB3 hFc is 250-800 ng/mL.

种属

Rhesus Macaque

表达系统

HEK293

标签

C-hFc

蛋白编号

XP_001113953 (S20-T643)

基因 ID
蛋白结构
N-term
HER3 (S20-T643)
Accession # XP_001113953
hFc
C-term
同用名
Receptor tyrosine-protein kinase erbB-3; ERBB3; HER3
氨基酸序列

SEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWKDIVRDQDAEIVVKDNGRSCPLCHEVCKGRCWGPGPEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMYNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLT

分子量

130-140 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

性状

溶液.

组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

N/A.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HER3 Protein, Rhesus Macaque (HEK293, Fc)
目录号:
HY-P76968
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