HER4 蛋白, Rat (HEK293, His)

HER4 Protein, crucial in central nervous system development, influences neural crest cell migration and axon guidance. Additionally, it participates in mammary gland differentiation, inducing milk proteins and contributing to lactation. HER4 Protein, Rat (HEK293, His) is the recombinant rat-derived HER4 protein, expressed by HEK293 , with C-His labeled tag. The total length of HER4 Protein, Rat (HEK293, His) is 626 a.a., with molecular weight of 75-95 kDa.

ERBB4 是一种在中枢神经系统发育、神经嵴细胞迁移和轴突引导中发挥重要作用的蛋白质。它还参与乳腺分化、乳蛋白诱导和哺乳。

Measured by its ability to inhibit the biological activity of Neuregulin-1-beta 1 on MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 3.464 μg/mL in the presence of 10 ng/mL. Recombinant Human NRG1‑beta1, corresponding to a specific activity is 288.6836 units/mg.

Rat

HEK293

C-His

Q62956 (Q26-P651)

59323  [NCBI]

QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQTWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTP

75-95 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.