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  4. hERG 蛋白, Human (HEK293, GFP, His)

hERG 蛋白, Human (HEK293, GFP, His)

目录号: HY-P701834
产品使用指南

hERG 蛋白是电压门控钾通道的 α 亚基，对于介导心脏延迟整流钾电流 (IKr) 至关重要。它缺乏单独的通道活性，但通过与其他亚型形成异四聚体来动态影响特性。hERG 蛋白, Human (HEK293, GFP, His) 是重组的 hERG 蛋白，由 HEK293 表达，带有 C-10*His, C-GFP 标签。hERG 蛋白, Human (HEK293, GFP, His) 。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293, GFP, His) is the recombinant human-derived hERG protein, expressed by HEK293 , with C-10*His, C-GFP labeled tag. ,
研究背景

hERG 是电压门控内向整流钾通道的成孔 (α) 亚基，在介导心脏延迟整流钾电流 (IKr) 的快速激活成分方面发挥着关键作用。虽然 hERG 本身缺乏通道活性，但它通过与其他亚型形成异四聚体来动态影响通道特性。这种亚基组装不仅调节通道特性，而且导致异四聚体保留在细胞内，随后经历泛素依赖性降解。hERG 与其他亚型之间错综复杂的相互作用突显了其在对心脏生理学至关重要的钾电流的微调中的调节功能。
种属

Human
表达系统

HEK293
标签

C-10*His;C-GFP
蛋白编号

Q12809
基因 ID

3757
同用名
KCNH2; Potassium voltage-gated channel subfamily H member 2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

hERG Protein, Human (HEK293, GFP, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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