HGF 蛋白, Rat (HEK293)

The HGF gene encodes hepatocyte growth factor (HGF), a protein involved in organ regeneration, angiogenesis, and myelination. It is located in the extracellular space and serves as a biomarker for cholangiocarcinoma. Implicated in various diseases, HGF plays a crucial role in physiological and pathological conditions. It shows biased expression in the liver (RPKM 137.5), lung (RPKM 132.1), and other tissues. HGF Protein, Rat (HEK293) is the recombinant rat-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Rat (HEK293) is 696 a.a., with molecular weight of ~92 kDa.

HGF 基因编码肝细胞生长因子 (HGF)，这是一种具有生长因子功能的蛋白质。HGF参与多种生物过程，包括动物器官再生、血管生成的正向调节和髓鞘形成的正向调节。它主要位于细胞外空间。HGF 被用作研究脑梗塞的工具，并作为胆管癌的生物标志物。HGF 基因的人类直系同源物与多种疾病有关，包括动脉疾病、常染色体隐性遗传性非综合征性耳聋 39、各种眼部疾病、神经病和多种形式的硬皮病，HGF 基因的人类直系同源物在多种生理和病理条件下发挥着至关重要的作用。HGF 在肝脏 (RPKM 137.5)、肺 (RPKM 132.1) 和其他八个组织中观察到偏向表达，它处于关键细胞过程和疾病途径的交叉点。

Measured in a cell proliferation assay using Mv-1-1u mink lung epithelial cells and the ED₅₀ is typically 1-6 ng/mL.

Rat

HEK293

Tag Free

NP_058713.1 (Q33-L728)

24446  [NCBI]

MMWGTKLLPVLLLQHVLLHLLLLPVTIPYAEGQKKRRNTLHEFKKSAKTTLTKEDPLVKIKTKKVNSADECANRCIRNKGFPFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLDPDTPWEYCAIKMCAHSAVNETDVPMETTECIKGQGEGYRGTTNTIWNGIPCQRWDSQYPHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDCYRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLTKNYCRNPDDDAHGPWCYTGNPLVPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGWMVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTGLINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLICEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL

Approximately 92 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.