HGFR 蛋白, Mouse (HEK293, Fc)

The HGFR protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix by binding to hepatocyte growth factor/HGF ligand. This interaction regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HGFR Protein, Mouse (HEK293, Fc) is 905 a.a., with molecular weight of ~43 kDa.

HGFR 蛋白是一种受体酪氨酸激酶，通过与肝细胞生长因子/HGF 配体结合，将信号从细胞外基质转导至细胞质。这种相互作用调节各种生理过程，包括增殖、散射、形态发生和细胞存活。配体结合后，HGFR 在其胞内结构域上发生自磷酸化，为下游信号分子（如 PIK3R1、PLCG1、SRC、GRB2、STAT3 和 GAB1）提供对接位点。HGFR 的激活会导致多个信号级联的激活，包括 RAS-ERK、PI3 激酶-AKT 和 PLCgamma-PKC。这些信号通路与形态发生效应、促生存效应以及各种发育过程的调节相关，例如原肠胚形成、神经元前体迁移、血管生成、肾脏形成和骨骼肌发育。在成人中，HGFR 参与伤口愈合、器官再生、组织重塑以及造血细胞的分化和增殖。此外，HGFR 作为单核细胞增生李斯特氏菌内源 InlB 的受体，使该病原体能够进入宿主细胞。此外，HGFR 可能在皮质骨成骨中发挥作用。

Mouse

HEK293

C-hFc

P16056 (E25-N929)

17295  [NCBI]

MKAPTVLAPGILVLLLSLVQRSHGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHGHHIYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLPCRDCSSKANSSGGVWKDNINMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNSADIQSEVHCMFSPEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPGYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFLDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPSDDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARSDEYRTEFTTALQRVDLFMGRLNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLGCGHFQSCSQCLSAPYFIQCGWCHNQCVRFDECPSGTWTQEICLPAVYKVFPTSAPLEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIISNSRETTQYSAFSYVDPVITSISPRYGPQAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTSDEFPVKLKIDLANRETSSFSYREDPVVYEIHPTKSFISGGSTITGIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEIICCTTPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTYVHNPVFEPFEKPVMISMGNENVVEIKGNNIDPEAVKGEVLKVGNQSCESLHWHSGAVLCTVPSDLLKLNSELNIEWKQAVSSTVLGKVIVQPDQN

Approximately 43 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.