HHLA2 蛋白, Human (HEK293, His)

HHLA2 protein, a key immune regulator, interacts with TMIGD2, providing crucial costimulation for T-cells during TCR-mediated activation. This interaction amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade, revealing HHLA2's role in enhancing T-cell responses and immune modulation. HHLA2 Protein, Human (HEK293, His) is the recombinant human-derived HHLA2 protein, expressed by HEK293 , with C-His labeled tag.

HHLA2 蛋白是免疫调节中的关键参与者，它与 TMIGD2 发生显着的相互作用，在 T 细胞受体 (TCR) 介导的激活过程中为 T 细胞提供共刺激。这种相互作用反过来又通过 AKT 依赖性信号级联放大 T 细胞增殖和细胞因子产生。HHLA2 和 TMIGD2 之间的合作强调了增强 T 细胞反应所涉及的复杂分子机制，揭示了其在免疫调节中的作用。

1. Immobilized HHLA2 Protein, Human, Recombinant (His Tag) at 2 μg/mL (100 μL/well) can bind CD28H/TMIGD2 Protein, Human, Recombinant (ECD, hFc Tag), the EC₅₀ is 33.3 ng/mL.
2. Loaded Recombinant Human B7-H7 / HHLA2 Protein, His Tag on His1K Biosensor, can bind Recombinant Human KIR3DL3 Protein, hFc Tag with an affinity constant of 18.5 nM as determined in BLI assay (Sartorius Octet RED384).

Human

HEK293

C-His

Q9UM44/NP_009003.1 (I23-N344)

11148  [NCBI]

Partial

Approximately 55 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.