HLA-C*0304 KRAS G12D Complex 蛋白, Human (GADGVGKSAL, HEK293, His-Avi)

The HLA-C*0304 KRAS G12D Complex, a major histocompatibility complex class I (MHCI) molecule, plays crucial roles in reproduction and antiviral immunity. Teaming up with B2M, it presents self and viral peptides, acting as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) on NK cells. In allogeneic contexts, it facilitates trophoblast interactions with NK cells, crucial for placental development. During viral infections, HLA-C*0304 may disrupt KIR-mediated inhibition and promote infected cell lysis. In adaptive immunity, it presents viral peptides to CD8-positive T cells, contributing to antigen-specific T cell responses in chronic viral infections. HLA-C*0304's fine specificity for antigen recognition and its role in immune surveillance stem from its ability to recognize diverse peptides and specific MHC residues. HLA-C*0304 KRAS G12D Complex Protein, Human (GADGVGKSAL, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-C*0304 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and GADGVGKSAL peptide. HLA-C*0304 KRAS G12D Complex Protein, Human (GADGVGKSAL, HEK293, His-Avi), has molecular weight of 55-65 kDa.

HLA-C*0304 是一种抗原呈递主要组织相容性复合物 I 类 (MHCI) 分子，在生殖和抗病毒免疫中发挥着关键作用。与 B2M/beta 2 微球蛋白结合，它表现出一系列特定的自身肽和病毒肽，作为 NK 细胞上抑制性和激活杀伤性免疫球蛋白受体 (KIR) 的主要配体。在同种异体环境中（例如怀孕期间）尤其重要，HLA-C*0304 促进绒毛外滋养层和表达 KIR 的子宫 NK 细胞之间的相互作用，调节对胎盘形成和胎儿整体生长至关重要的滋养层侵袭。在病毒感染期间，HLA-C*0304 可能会呈递对 KIR 具有低亲和力的病毒肽，通过肽拮抗作用破坏 KIR 介导的抑制并促进受感染细胞的裂解。在适应性免疫领域，HLA-C*0304 向 CD8 阳性 T 细胞呈现有限的病毒肽库，从而实现针对感染细胞的抗原特异性 T 细胞免疫反应，特别是在 HIV-1 或 CMV 等慢性病毒感染中。肽与等位基因特异性基序（由位置 2 和 9 处的锚定残基定义）的结合展示了 HLA-C*0304 识别由蛋白酶体胞质蛋白水解产生的多种肽抗原的能力。该肽对抗原识别的良好特异性以及负责 T 细胞 MHC 限制的 MHC 残基共同促成了 HLA-C*0304 在免疫监视中的作用。

Human

HEK293

C-Avi;C-His

QAV56463.1 (G25-T305)&P61769 (I21-M119)&GADGVGKSAL

/&567

55-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.