HMGN1 蛋白, Human

The HMGN1 protein is a key player in the immune response, binding to the Fc region of immunoglobulin alpha and specifically promoting the production of cytokines. HMGN1 is intricately related to the Fc epsilon RI gamma 2 receptor, can induce tyrosine phosphorylation of gamma 2, and actively participates in the complex coordination of immune signaling pathways. HMGN1 Protein, Human is the recombinant human-derived HMGN1 protein, expressed by E. coli , with tag free.

FCAR/CD89 是免疫反应中的关键参与者，具有与免疫球蛋白 α 的 Fc 区结合的能力，促进各种功能，特别是细胞因子的产生。这种多面蛋白与 Fc epsilon RI gamma 2 受体错综复杂地相关，从而诱导 gamma 2 的酪氨酸磷酸化。通过这些分子相互作用，FCAR/CD89 积极参与免疫信号通路的复杂编排，突出了其在介导中的作用免疫反应的关键方面。

Measured by its binding ability in a functional ELISA. Immobilized HMGN1 at 2 μg/mL (100 μL/well) can bind anti- HMGN1 Antibody. The ED₅₀ for this effect is 57.03 ng/mL.

Human

E. coli

Tag Free

P05114 (P2-D100)

3150  [NCBI]

Approximately 19 kDa, based on SDS-PAGE under reducing conditions.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 500 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.