HNF4A 蛋白, Human (HEK293, His, solution)

HNF 4 alpha, a nuclear transcription factor, forms homodimers to bind DNA. It regulates gene expression, including hepatocyte nuclear factor 1 alpha, impacting hepatic genes. Its involvement extends to liver, kidney, and intestinal development. Mutations associate with autosomal dominant non-insulin-dependent diabetes mellitus type I. The gene exhibits biased expression in the duodenum (RPKM 37.7) and colon (RPKM 32.8), among other tissues. HNF4A Protein, Human (HEK293, His, solution) is the recombinant human-derived HNF 4 alpha, expressed by HEK293 , with C-10*His labeled tag.

HNF 4 α 是该基因的蛋白质产物，充当核转录因子，形成同二聚体以结合 DNA 并控制各种基因的表达，包括肝细胞核因子 1 α（肝基因表达的关键调节因子）。它的参与延伸到肝脏、肾脏和肠道等重要器官的发育。HNF 4α 突变与单基因常染色体显性非胰岛素依赖型 I 型糖尿病有关，强调了其在代谢调节中的重要性。此外，选择性剪接会产生多种转录变体，从而产生不同的亚型。值得注意的是，HNF 4 α 表现出偏向表达，在十二指肠 (RPKM 37.7)、结肠 (RPKM 32.8) 和其他七个组织中观察到较高水平，强调了其在不同生理环境中的特殊作用。

Human

HEK293

C-10*His

P41235-1/NP_000448 (M1-I474)

3172

Full Length of Isoform-1

MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI

Approximately 70-80 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.