HPRG 蛋白, Rat (HEK293, His)

Heparin-binding protein (HPRG) is a versatile plasma glycoprotein regulating immune processes, cell adhesion, and angiogenesis. It binds ligands like heparin and thrombospondins, modulates phagocytosis, and interacts with proteins including HPSE, TMP1, and PLG, influencing diverse cellular functions. HPRG Protein, Rat (HEK293, His) is the recombinant rat-derived HPRG protein, expressed by HEK293 , with C-His labeled tag. The total length of HPRG Protein, Rat (HEK293, His) is 525 a.a., with molecular weight of ~58.6 KDa.

肝素结合蛋白 (HPRG) 是一种多功能血浆糖蛋白，以其结合各种配体的能力而闻名，包括血红素、肝素、硫酸乙酰肝素、血小板反应蛋白、纤溶酶原和二价金属离子。作为衔接蛋白，HPRG 参与多种生理过程的调节，例如免疫复合物和病原体清除、细胞粘附、血管生成、凝血和纤溶。它的参与延伸到通过增强的吞噬途径介导坏死细胞的清除，这依赖于硫酸乙酰肝素。该过程受到特定 HPRG 配体（包括肝素和锌离子）的调节。HPRG 对具有 kappa 和 lambda 轻链的免疫球蛋白 IgG 亚类表现出亲和力，在其清除和抑制不溶性免疫复合物的形成中发挥调节作用。此外，HPRG 将纤溶酶原束缚在细胞表面并与 T 细胞相互作用，影响其形态。值得注意的是，它通过与 CD36 相互作用，抵消血小板反应蛋白（特别是 THBS1 和 THBS2）的抗血管生成作用，从而调节血管生成。此外，HPRG 与多种蛋白质相互作用，包括 HPSE、TMP1、F12、PLG 和 TPM1，有助于其参与多种细胞和分子过程。

Rat

HEK293

C-His

Q99PS8 (M1-K525)

171016  [NCBI]

Approximately 58.6 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.