HSP40/DNAJB1 蛋白, Human (His)

HSP40/DNAJB1 protein, a key player in cellular processes, interacts with HSP70 to enhance ATPase activity and stimulate HSC70-HIP association. It negatively regulates HSF1 transcriptional activity in heat shock response recovery, and interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity. These multifaceted interactions showcase HSP40/DNAJB1's intricate regulatory functions in stress responses and protein folding. HSP40/DNAJB1 Protein, Human (His) is the recombinant human-derived HSP40/DNAJB1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSP40/DNAJB1 Protein, Human (His) is 339 a.a., with molecular weight of ~38.0 kDa.

HSP40/DNAJB1 蛋白通过与各种伙伴的相互作用在细胞过程中发挥着至关重要的作用。它与 HSP70 相互作用，增强其 ATP 酶活性并刺激 HSC70 和 HIP 之间的关联。此外，HSP40/DNAJB1 在热休克反应的减弱和恢复阶段负向调节 HSF1 的转录活性，证明了其在调节热休克诱导过程中的作用。此外，HSP40/DNAJB1 与 DNAJC3 和 HSF1 相互作用，在热休克反应的恢复阶段抑制它们的转录活性。这些相互作用凸显了 HSP40/DNAJB1 在协调细胞对应激和蛋白质折叠的反应方面的多方面性质，揭示了其复杂的调节功能。

Human

E. coli

C-6*His

P25685 (G2-I340)

3337  [NCBI]

GKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEGLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGEGLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI

Approximately 38.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.