1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules
  5. Intercellular Adhesion Molecule 1 (ICAM-1)
  6. ICAM-1/CD54 蛋白, Rat (HEK293, Fc)

ICAM-1/CD54 蛋白, Rat (HEK293, Fc)

目录号: HY-P73909
产品使用指南

ICAM-1/CD54 蛋白是白细胞粘附的重要配体,在迁移过程中促进内皮细胞顶杯组装。它调节免疫反应和炎症。ICAM-1 还与 MUC1 相互作用,促进细胞聚集,并有助于抗原呈递细胞和 T 细胞之间免疫突触的形成。这些相互作用展示了 ICAM-1 在细胞粘附和免疫调节方面的多种功能。ICAM-1/CD54 蛋白, Rat (HEK293, Fc) 是重组的 ICAM-1/CD54 蛋白,由 HEK293 表达,带有 C-hFc 标签。ICAM-1/CD54 蛋白, Rat (HEK293, Fc) 全长 466 个氨基酸,分子量约为 ~77.6 kDa。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

ICAM-1/CD54 protein is a crucial ligand for leukocyte adhesion, promoting endothelial apical cup assembly during migration. It regulates immune responses and inflammation. ICAM-1 also interacts with MUC1, promoting cell aggregation, and contributes to immunological synapse formation between antigen-presenting cells and T cells. These interactions showcase ICAM-1's diverse functions in cellular adhesion and immune modulation. ICAM-1/CD54 Protein, Rat (HEK293, Fc) is the recombinant rat-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ICAM-1/CD54 Protein, Rat (HEK293, Fc) is 466 a.a., with molecular weight of ~77.6 kDa.

研究背景

ICAM-1/CD54 蛋白是白细胞粘附蛋白 LFA-1(整合素 α-L/β-2)的关键配体,在多种细胞相互作用中发挥着关键作用。具体而言,在白细胞跨内皮迁移过程中,ICAM-1 的参与通过 ARHGEF26/SGEF 和 RHOG 的激活促进内皮顶杯的组装。这种复杂的分子过程让人想起其他 ICAM 家族成员,强调了 ICAM-1 参与调节免疫反应和炎症反应。除了在白细胞粘附中的作用外,ICAM-1 还形成同二聚体并与 MUC1 相互作用,促进上皮细胞中的细胞聚集。此外,ICAM-1 与 ARHGEF26/SGEF 结合,并在 T 细胞侧与 CD81、CD247 和 CD9 相互作用,有助于在抗原呈递细胞和 T 细胞之间建立免疫突触。这些多功能的相互作用凸显了 ICAM-1 在细胞粘附和免疫调节中的多方面功能。

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

Q00238 (Q28-T493)

基因 ID

25464  [NCBI]

蛋白结构
N-term
ICAM-1 (Q28-T493)
Accession # Q00238
hFc
C-term
同用名
Intercellular Adhesion Molecule 1; ICAM-1; CD54
分子量

Approximately 77.6 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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ICAM-1/CD54 Protein, Rat (HEK293, Fc)
目录号:
HY-P73909
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