1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules
  5. Intercellular Adhesion Molecule 1 (ICAM-1)
  6. ICAM-1/CD54 蛋白, Rhesus Macaque (HEK293, His)

ICAM-1/CD54 蛋白, Rhesus Macaque (HEK293, His)

目录号: HY-P74873
产品使用指南

ICAM-1/CD54 蛋白是白细胞粘附蛋白 LFA-1 的配体,对于白细胞跨内皮迁移至关重要。它的参与激活 ARHGEF26/SGEF 和 RHOG,协调内皮顶杯组装。ICAM-1/CD54 蛋白, Rhesus Macaque (HEK293, His) 是重组的 ICAM-1/CD54 蛋白,由 HEK293 表达,带有 C-6*His 标签。ICAM-1/CD54 蛋白, Rhesus Macaque (HEK293, His) 全长 453 个氨基酸,分子量为 70-115 kDa。

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描述

The ICAM-1/CD54 protein is a ligand of the leukocyte adhesion protein LFA-1 and is critical for leukocyte transendothelial migration. Its involvement activates ARHGEF26/SGEF and RHOG, coordinating endothelial apical cup assembly. ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His) is 453 a.a., with molecular weight of 70-115 kDa.

研究背景

ICAM-1/CD54 蛋白作为白细胞粘附蛋白 LFA-1(整合素 α-L/β-2)的配体,在白细胞跨内皮迁移中发挥着至关重要的作用。在此过程中 ICAM-1 的参与通过 ARHGEF26/SGEF 和 RHOG 的激活促进内皮顶端杯的组装,揭示其参与协调动态细胞事件(通过相似性)。ICAM-1 还形成同二聚体并与 MUC1 相互作用,促进上皮细胞中的细胞聚集。此外,它与 ARHGEF26/SGEF 的相互作用强调了它参与调节细胞动力学的信号通路。在T细胞方面,ICAM-1在抗原呈递细胞和T细胞之间的免疫突触处与CD81、CD247和CD9相互作用,强调了其在免疫突触形成过程中免疫细胞相互作用中的关键作用。ICAM-1 的多方面相互作用凸显了其在介导多种细胞过程和促进细胞间通讯方面的重要性。

种属

Rhesus Macaque

表达系统

HEK293

标签

C-6*His

蛋白编号

Q5NKV6 (Q28-E480)

基因 ID

712280  [NCBI]

蛋白结构
N-term
ICAM-1 (Q28-E480)
Accession # Q5NKV6
6*His
C-term
同用名
Intercellular Adhesion Molecule 1; ICAM-1; CD54
分子量

70-115 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His)
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HY-P74873
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